Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides. [electronic resource]
- Journal of neurovirology Apr 2016
- 129-39 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1538-2443
10.1007/s13365-015-0397-0 doi
Blood-Brain Barrier--drug effects Cell Line Chemokine CCL5--genetics Drug Carriers--pharmacology Endothelial Cells--cytology Escherichia coli--genetics Exosomes--metabolism Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins--genetics HEK293 Cells HIV-1--chemistry Humans Interleukins--genetics Magnetite Nanoparticles--chemistry Microglia--cytology Models, Biological Peptides--chemical synthesis Signal Transduction Transfection Transgenes nef Gene Products, Human Immunodeficiency Virus--antagonists & inhibitors