Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. [electronic resource]
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine May 2016
- 6155-68 p. digital
Publication Type: Journal Article
1423-0380
10.1007/s13277-015-4348-4 doi
Aged Aged, 80 and over Apoptosis--drug effects Biomarkers, Tumor Cell Hypoxia Cell Line, Tumor Colonic Neoplasms--genetics Enzyme Activation Enzyme Inhibitors--pharmacology Female Gene Expression Humans Inhibitor of Apoptosis Proteins--genetics Male Middle Aged Neoplasm Metastasis Neoplasm Staging Phosphatidylinositol 3-Kinases--metabolism Phospholipase D--antagonists & inhibitors Proto-Oncogene Proteins c-akt--metabolism Proto-Oncogene Proteins c-bcl-2--genetics Signal Transduction Survivin