Fellerhoff-Losch, Barbara

Normal human CD4(+) helper T cells express Kv1.1 voltage-gated K(+) channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway. [electronic resource] - Journal of neural transmission (Vienna, Austria : 1996) Mar 2016 - 137-57 p. digital

Publication Type: Journal Article

1435-1463

10.1007/s00702-015-1446-9 doi


Animals
Autoimmune Diseases--immunology
Blotting, Western
CD4-Positive T-Lymphocytes--immunology
Electrophoretic Mobility Shift Assay
Female
Humans
Immunohistochemistry
Inflammation--immunology
Kv1.1 Potassium Channel--metabolism
Male
Mice
Mice, SCID
NF-kappa B--immunology
Patch-Clamp Techniques
Polymerase Chain Reaction
Signal Transduction--immunology
Tumor Necrosis Factor-alpha--metabolism