TY - GEN AU - Tardito,Saverio AU - Oudin,Anaïs AU - Ahmed,Shafiq U AU - Fack,Fred AU - Keunen,Olivier AU - Zheng,Liang AU - Miletic,Hrvoje AU - Sakariassen,Per Øystein AU - Weinstock,Adam AU - Wagner,Allon AU - Lindsay,Susan L AU - Hock,Andreas K AU - Barnett,Susan C AU - Ruppin,Eytan AU - Mørkve,Svein Harald AU - Lund-Johansen,Morten AU - Chalmers,Anthony J AU - Bjerkvig,Rolf AU - Niclou,Simone P AU - Gottlieb,Eyal TI - Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma SN - 1476-4679 PY - 2016///0401 KW - Animals KW - Astrocytes KW - cytology KW - Blotting, Western KW - Brain Neoplasms KW - genetics KW - Cell Line, Tumor KW - Cell Proliferation KW - Cells, Cultured KW - Citric Acid Cycle KW - Coculture Techniques KW - Female KW - Glioblastoma KW - Glutamate-Ammonia Ligase KW - Glutamic Acid KW - metabolism KW - Glutamine KW - Humans KW - Male KW - Mice, Inbred NOD KW - Mice, SCID KW - Models, Biological KW - Neoplastic Stem Cells KW - Nucleotides KW - biosynthesis KW - Rats, Sprague-Dawley KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transplantation, Heterologous N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/ncb3272 ER -