TY - GEN AU - Huang,Kuo-Yen AU - Kao,Shih-Han AU - Wang,Wen-Lung AU - Chen,Chi-Yuan AU - Hsiao,Tzu-Hung AU - Salunke,Santosh B AU - Chen,Jeremy J W AU - Su,Kang-Yi AU - Yang,Shuenn-Chen AU - Hong,Tse-Ming AU - Chen,Ching-Shih AU - Yang,Pan-Chyr TI - Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation SN - 1535-4970 PY - 2016///0812 KW - Adaptor Proteins, Signal Transducing KW - drug effects KW - Adenocarcinoma KW - drug therapy KW - Adenocarcinoma of Lung KW - Afatinib KW - Animals KW - Antineoplastic Agents KW - adverse effects KW - Blotting, Western KW - Cell Proliferation KW - Drug Combinations KW - Drug Resistance, Neoplasm KW - Enzyme Assays KW - ErbB Receptors KW - antagonists & inhibitors KW - Humans KW - Lung Neoplasms KW - Mass Spectrometry KW - Mice KW - Mutation KW - genetics KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins c-cbl KW - Quinazolines KW - Real-Time Polymerase Chain Reaction KW - Tumor Cells, Cultured KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1164/rccm.201502-0250OC ER -