Inhibition of autophagy induced by PTEN loss promotes intrinsic breast cancer resistance to trastuzumab therapy. [electronic resource]
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Apr 2016
- 5445-54 p. digital
Publication Type: Journal Article
1423-0380
10.1007/s13277-015-4392-0 doi
Animals Autophagy--drug effects Breast Neoplasms--drug therapy Cell Line, Tumor Drug Resistance, Neoplasm--genetics Female Gene Expression Regulation, Neoplastic--drug effects Humans Mice Microtubule-Associated Proteins--biosynthesis PTEN Phosphohydrolase--genetics RNA-Binding Proteins--biosynthesis Receptor, ErbB-2--genetics Signal Transduction TOR Serine-Threonine Kinases--biosynthesis Trastuzumab--administration & dosage Xenograft Model Antitumor Assays