TY - GEN AU - Zhu,Yan AU - Tian,Tiantian AU - Zou,Jianling AU - Wang,Qiwei AU - Li,Zhongwu AU - Li,Yanyan AU - Liu,Xijuan AU - Dong,Bin AU - Li,Na AU - Gao,Jing AU - Shen,Lin TI - Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer SN - 1471-2407 PY - 2016///0819 KW - Animals KW - Antineoplastic Agents KW - pharmacology KW - Apoptosis KW - drug effects KW - Cell Cycle KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Disease Models, Animal KW - Dose-Response Relationship, Drug KW - Drug Resistance, Neoplasm KW - G1 Phase Cell Cycle Checkpoints KW - Humans KW - Imidazoles KW - Mice KW - Phosphoinositide-3 Kinase Inhibitors KW - Quinolines KW - Receptor, ErbB-2 KW - metabolism KW - Signal Transduction KW - Stomach Neoplasms KW - drug therapy KW - TOR Serine-Threonine Kinases KW - antagonists & inhibitors KW - Trastuzumab KW - Tumor Burden KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/s12885-015-1900-y ER -