Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia. [electronic resource]
- BMC cancer Nov 2015
- 869 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1471-2407
10.1186/s12885-015-1695-x doi
Apoptosis--drug effects Azacitidine--pharmacology Carbazoles--pharmacology Cell Line, Tumor Cells, Cultured DNA Methylation Drug Resistance, Neoplasm--genetics Furans Gene Duplication Gene Expression Regulation, Leukemic--drug effects Humans Leukemia, Myeloid, Acute--drug therapy Protein Tyrosine Phosphatase, Non-Receptor Type 6--genetics STAT3 Transcription Factor--metabolism fms-Like Tyrosine Kinase 3--genetics