Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance. [electronic resource]
- International journal of cancer Apr 2016
- 1645-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0215
10.1002/ijc.29919 doi
Adult Alternative Splicing Antineoplastic Agents--therapeutic use Blotting, Western Child Drug Resistance, Neoplasm--physiology Female Flow Cytometry Humans Male Methotrexate--therapeutic use Peptide Synthases--metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction