Ellard, John M <br/><br/>
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Dec 2015 
 - 5792-6 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2015.10.050  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Animals<br/>Antipsychotic Agents--chemistry<br/>Astrocytes--cytology<br/>Cognition--drug effects<br/>Disease Models, Animal<br/>Drug Evaluation, Preclinical<br/>Half-Life<br/>Humans<br/>Microsomes--metabolism<br/>Rats<br/>Receptor, Metabotropic Glutamate 5--antagonists & inhibitors<br/>Structure-Activity Relationship<br/>Triazoles--chemistry