Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed. [electronic resource]
- Journal of structural biology Dec 2015
- 539-544 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1095-8657
10.1016/j.jsb.2015.10.018 doi
Acrylamides--metabolism Aniline Compounds--metabolism Antineoplastic Agents--pharmacology Crystallography, X-Ray Drug Resistance, Neoplasm--genetics ErbB Receptors--antagonists & inhibitors Erlotinib Hydrochloride--pharmacology Gefitinib Humans Lung Neoplasms--drug therapy Protein Binding--physiology Protein Kinase Inhibitors--pharmacology Quinazolines--pharmacology