TY  - GEN
AU  - Huang,Qiang
AU  - Zhou,Changhua
AU  - Chen,Xiao
AU  - Dong,Bing
AU  - Chen,Siqi
AU  - Zhang,Ning
AU  - Liu,Yawei
AU  - Li,Anrong
AU  - Yao,Meicun
AU  - Miao,Ji
AU  - Li,Qing
AU  - Wang,Zhong
TI  - Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib
SN  - 1932-6203
PY  - 2016///0621
KW  - Angiogenesis Inhibitors
KW  - administration & dosage
KW  - Animals
KW  - Antineoplastic Agents
KW  - Benzoates
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Disease Models, Animal
KW  - Drug Synergism
KW  - Drug Tolerance
KW  - Esterases
KW  - metabolism
KW  - Female
KW  - Humans
KW  - Hydrolysis
KW  - Indoles
KW  - Mice
KW  - Neoplasms
KW  - drug therapy
KW  - Phosphorylation
KW  - Prodrugs
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-akt
KW  - Pyrroles
KW  - STAT3 Transcription Factor
KW  - Sunitinib
KW  - Tissue Distribution
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0141395
ER  -