Huang, Qiang <br/><br/>
Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib.  [electronic resource] 

 -  PloS one  2015 
 - e0141395 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1932-6203 
<br/><br/><label>Standard No.: </label>10.1371/journal.pone.0141395  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Angiogenesis Inhibitors--administration & dosage<br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Benzoates--administration & dosage<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Disease Models, Animal<br/>Drug Synergism<br/>Drug Tolerance<br/>Esterases--metabolism<br/>Female<br/>Humans<br/>Hydrolysis<br/>Indoles--administration & dosage<br/>Mice<br/>Neoplasms--drug therapy<br/>Phosphorylation--drug effects<br/>Prodrugs--administration & dosage<br/>Protein Kinase Inhibitors--administration & dosage<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Pyrroles--administration & dosage<br/>STAT3 Transcription Factor--metabolism<br/>Sunitinib<br/>Tissue Distribution<br/>Tumor Burden--drug effects<br/>Xenograft Model Antitumor Assays