TY - GEN AU - Ramcharan,Roger AU - Aleksic,Tamara AU - Kamdoum,Wilfride Petnga AU - Gao,Shan AU - Pfister,Sophia X AU - Tanner,Jordan AU - Bridges,Esther AU - Asher,Ruth AU - Watson,Amanda J AU - Margison,Geoffrey P AU - Woodcock,Mick AU - Repapi,Emmanouela AU - Li,Ji-Liang AU - Middleton,Mark R AU - Macaulay,Valentine M TI - IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide SN - 1949-2553 PY - 2016///0920 KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Apoptosis KW - drug effects KW - Blotting, Western KW - Cell Line, Tumor KW - Cell Survival KW - DNA Breaks, Double-Stranded KW - Dacarbazine KW - administration & dosage KW - Drug Administration Schedule KW - Drug Resistance, Neoplasm KW - Drug Synergism KW - G1 Phase Cell Cycle Checkpoints KW - Humans KW - Imidazoles KW - Melanoma KW - drug therapy KW - Mice, Inbred BALB C KW - Mice, Nude KW - Mutation KW - Proto-Oncogene Proteins B-raf KW - genetics KW - Pyrazines KW - Receptor, IGF Type 1 KW - antagonists & inhibitors KW - Survival Analysis KW - Temozolomide KW - Tumor Suppressor Protein p53 KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.18632/oncotarget.5631 ER -