IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. [electronic resource]
- Oncotarget Nov 2015
- 39877-90 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.5631 doi
Animals Antineoplastic Combined Chemotherapy Protocols--pharmacology Apoptosis--drug effects Blotting, Western Cell Line, Tumor Cell Survival--drug effects DNA Breaks, Double-Stranded--drug effects Dacarbazine--administration & dosage Drug Administration Schedule Drug Resistance, Neoplasm--drug effects Drug Synergism G1 Phase Cell Cycle Checkpoints--drug effects Humans Imidazoles--administration & dosage Melanoma--drug therapy Mice, Inbred BALB C Mice, Nude Mutation Proto-Oncogene Proteins B-raf--genetics Pyrazines--administration & dosage Receptor, IGF Type 1--antagonists & inhibitors Survival Analysis Temozolomide Tumor Suppressor Protein p53--genetics Xenograft Model Antitumor Assays