TY  - GEN
AU  - Ma,Shuang
AU  - Yang,Ling-Ling
AU  - Niu,Ting
AU  - Cheng,Chuan
AU  - Zhong,Lei
AU  - Zheng,Ming-Wu
AU  - Xiong,Yu
AU  - Li,Lin-Li
AU  - Xiang,Rong
AU  - Chen,Li-Juan
AU  - Zhou,Qiao
AU  - Wei,Yu-Quan
AU  - Yang,Sheng-Yong
TI  - SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML
SN  - 2045-2322
PY  - 2016///0915
KW  - Animals
KW  - Animals, Genetically Modified
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Cell Survival
KW  - Drug Resistance, Neoplasm
KW  - Female
KW  - G1 Phase Cell Cycle Checkpoints
KW  - Humans
KW  - Isoxazoles
KW  - Leukemia, Myeloid, Acute
KW  - drug therapy
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Phenylurea Compounds
KW  - chemistry
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Urea
KW  - analogs & derivatives
KW  - Wnt Proteins
KW  - antagonists & inhibitors
KW  - Wnt Signaling Pathway
KW  - Zebrafish
KW  - beta Catenin
KW  - fms-Like Tyrosine Kinase 3
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/srep15646
ER  -