TY  - GEN
AU  - Boy,Kenneth M
AU  - Guernon,Jason M
AU  - Wu,Yong-Jin
AU  - Zhang,Yunhui
AU  - Shi,Joe
AU  - Zhai,Weixu
AU  - Zhu,Shirong
AU  - Gerritz,Samuel W
AU  - Toyn,Jeremy H
AU  - Meredith,Jere E
AU  - Barten,Donna M
AU  - Burton,Catherine R
AU  - Albright,Charles F
AU  - Good,Andrew C
AU  - Grace,James E
AU  - Lentz,Kimberley A
AU  - Olson,Richard E
AU  - Macor,John E
AU  - Thompson,Lorin A
TI  - Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
SN  - 1464-3405
PY  - 2016///0811
KW  - ATP Binding Cassette Transporter, Subfamily B, Member 1
KW  - metabolism
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Peptides
KW  - biosynthesis
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Caco-2 Cells
KW  - Cathepsin D
KW  - Cathepsin E
KW  - Dogs
KW  - Guanidines
KW  - chemical synthesis
KW  - Humans
KW  - Macrocyclic Compounds
KW  - Madin Darby Canine Kidney Cells
KW  - Male
KW  - Mice
KW  - Molecular Docking Simulation
KW  - Pepsin A
KW  - Proline
KW  - analogs & derivatives
KW  - Protease Inhibitors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2015.10.031
ER  -