Boy, Kenneth M <br/><br/>
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE).  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Nov 2015 
 - 5040-7 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2015.10.031  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Peptides--biosynthesis<br/>Animals<br/>Aspartic Acid Endopeptidases--antagonists & inhibitors<br/>Caco-2 Cells<br/>Cathepsin D--antagonists & inhibitors<br/>Cathepsin E--antagonists & inhibitors<br/>Dogs<br/>Guanidines--chemical synthesis<br/>Humans<br/>Macrocyclic Compounds--chemical synthesis<br/>Madin Darby Canine Kidney Cells<br/>Male<br/>Mice<br/>Molecular Docking Simulation<br/>Pepsin A--antagonists & inhibitors<br/>Proline--analogs & derivatives<br/>Protease Inhibitors--chemical synthesis