TY  - GEN
AU  - Garcia-Barrantes,Pedro M
AU  - Cho,Hyekyung P
AU  - Blobaum,Anna L
AU  - Niswender,Colleen M
AU  - Conn,P Jeffrey
AU  - Lindsley,Craig W
TI  - Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core
SN  - 1464-3405
PY  - 2016///0811
KW  - Allosteric Regulation
KW  - Animals
KW  - Brain
KW  - metabolism
KW  - Coumarins
KW  - blood
KW  - Furans
KW  - Humans
KW  - Microsomes, Liver
KW  - Phthalimides
KW  - Rats
KW  - Receptors, Metabotropic Glutamate
KW  - agonists
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmcl.2015.10.013
ER  -