Piegeler, T <br/><br/>
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.  [electronic resource] 

 -  British journal of anaesthesia  Nov 2015 
 - 784-91 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1471-6771 
<br/><br/><label>Standard No.: </label>10.1093/bja/aev341  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenocarcinoma--metabolism<br/>Adenocarcinoma of Lung<br/>Amides--pharmacology<br/>Anesthetics, Local--pharmacology<br/>Caveolin 1--metabolism<br/>Cell Movement--drug effects<br/>Drug Evaluation, Preclinical--methods<br/>Enzyme Activation--drug effects<br/>Focal Adhesion Protein-Tyrosine Kinases--metabolism<br/>Humans<br/>Lidocaine--pharmacology<br/>Lung Neoplasms--metabolism<br/>Matrix Metalloproteinase 9--metabolism<br/>Neoplasm Invasiveness<br/>Neoplasm Proteins--metabolism<br/>Phosphorylation--drug effects<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Ropivacaine<br/>Tumor Cells, Cultured<br/>Tumor Necrosis Factor-alpha--antagonists & inhibitors