TY - GEN AU - Hu,Hongxiang AU - Lin,Zhiqiang AU - He,Bing AU - Dai,Wenbing AU - Wang,Xueqing AU - Wang,Jiancheng AU - Zhang,Xuan AU - Zhang,Hua AU - Zhang,Qiang TI - A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel SN - 1873-4995 PY - 2017///0110 KW - ATP Binding Cassette Transporter, Subfamily B KW - antagonists & inhibitors KW - Administration, Oral KW - Animals KW - Antineoplastic Agents, Phytogenic KW - administration & dosage KW - Breast Neoplasms KW - drug therapy KW - Cell Survival KW - drug effects KW - Delayed-Action Preparations KW - Dose-Response Relationship, Drug KW - Drug Carriers KW - Drug Combinations KW - Drug Compounding KW - Drug Synergism KW - Female KW - G2 Phase Cell Cycle Checkpoints KW - Humans KW - Hydrogels KW - Injections, Intralesional KW - Injections, Intravenous KW - Lapatinib KW - MCF-7 Cells KW - Mice, Inbred BALB C KW - Mice, Nude KW - Nanoparticles KW - Nanotechnology KW - Paclitaxel KW - Poloxamer KW - chemistry KW - Protein Kinase Inhibitors KW - Quinazolines KW - Receptor, ErbB-2 KW - Solubility KW - Technology, Pharmaceutical KW - methods KW - Temperature KW - Time Factors KW - Tumor Burden KW - Xenograft Model Antitumor Assays N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.jconrel.2015.10.018 ER -