A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel. [electronic resource]
- Journal of controlled release : official journal of the Controlled Release Society Dec 2015
- 189-200 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1873-4995
10.1016/j.jconrel.2015.10.018 doi
ATP Binding Cassette Transporter, Subfamily B--antagonists & inhibitors Administration, Oral Animals Antineoplastic Agents, Phytogenic--administration & dosage Breast Neoplasms--drug therapy Cell Survival--drug effects Delayed-Action Preparations Dose-Response Relationship, Drug Drug Carriers Drug Combinations Drug Compounding Drug Synergism Female G2 Phase Cell Cycle Checkpoints--drug effects Humans Hydrogels Injections, Intralesional Injections, Intravenous Lapatinib MCF-7 Cells Mice, Inbred BALB C Mice, Nude Nanoparticles Nanotechnology Paclitaxel--administration & dosage Poloxamer--chemistry Protein Kinase Inhibitors--administration & dosage Quinazolines--administration & dosage Receptor, ErbB-2--antagonists & inhibitors Solubility Technology, Pharmaceutical--methods Temperature Time Factors Tumor Burden--drug effects Xenograft Model Antitumor Assays