Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway. [electronic resource]
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Mar 2016
- 3665-73 p. digital
Publication Type: Journal Article
1423-0380
10.1007/s13277-015-3265-x doi
Apoptosis--drug effects Blotting, Western Breast Neoplasms--metabolism Cell Line, Tumor Cell Survival--drug effects Diphosphonates--pharmacology Dose-Response Relationship, Drug Drug Synergism Enzyme Inhibitors--pharmacology Female Humans Imidazoles--pharmacology MCF-7 Cells Marine Toxins Okadaic Acid--pharmacology Oxazoles--pharmacology Phosphatidylinositol 3-Kinases--metabolism Phosphoprotein Phosphatases--antagonists & inhibitors Proto-Oncogene Proteins c-akt--metabolism Signal Transduction--drug effects Zoledronic Acid