Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1. [electronic resource]
- Biological psychiatry 08 2016
- 302-311 p. digital
Publication Type: Journal Article
1873-2402
10.1016/j.biopsych.2015.08.028 doi
Age Factors Animals Animals, Newborn Dendritic Spines--drug effects Disease Models, Animal Disks Large Homolog 4 Protein Epileptic Syndromes Gene Expression Regulation, Developmental--drug effects Green Fluorescent Proteins--genetics Guanylate Kinases--metabolism Insulin-Like Growth Factor I--therapeutic use Long-Term Potentiation--drug effects Membrane Proteins--metabolism Mice Mice, Transgenic Patch-Clamp Techniques Phosphorylation--drug effects Protein Serine-Threonine Kinases--deficiency Pyramidal Cells--pathology Rett Syndrome--drug therapy Somatosensory Cortex--pathology Spasms, Infantile--drug therapy Synapses--drug effects