John, Jubi <br/><br/>
Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.  [electronic resource] 

 -  Journal of medicinal chemistry  Oct 2015 
 - 8110-27 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b01180  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antiviral Agents--chemical synthesis<br/>DNA Polymerase I--antagonists & inhibitors<br/>DNA Polymerase beta--antagonists & inhibitors<br/>DNA Primers<br/>Drug Design<br/>HIV Reverse Transcriptase--antagonists & inhibitors<br/>HIV-1--drug effects<br/>Herpesvirus 3, Human--drug effects<br/>Humans<br/>Molecular Conformation<br/>Nucleic Acid Synthesis Inhibitors--chemical synthesis<br/>Organophosphonates--chemical synthesis<br/>Plasmids--genetics<br/>Reverse Transcriptase Inhibitors--chemical synthesis<br/>Simplexvirus--drug effects<br/>Structure-Activity Relationship