Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. [electronic resource]
- Biochemical and biophysical research communications Nov 2015
- 407-12 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1090-2104
10.1016/j.bbrc.2015.09.137 doi
Animals Cell Line Checkpoint Kinase 1 Checkpoint Kinase 2--genetics Crosses, Genetic Cyclic N-Oxides--pharmacology DNA Damage Diabetes, Gestational--chemically induced Embryo, Mammalian Female Gene Expression Regulation Glucose--antagonists & inhibitors Histones--genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Neural Stem Cells--drug effects Neurulation--genetics Oxidative Stress Phosphorylation Pregnancy Protein Kinases--genetics Signal Transduction Spin Labels Streptozocin Superoxide Dismutase--deficiency Superoxide Dismutase-1 Tumor Suppressor Protein p53--genetics