Gong, Xuezhong <br/><br/>
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.  [electronic resource] 

 -  Archives of toxicology  Sep 2016 
 - 2187-2200 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1432-0738 
<br/><br/><label>Standard No.: </label>10.1007/s00204-015-1600-z  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antioxidants--pharmacology<br/>Apoptosis--drug effects<br/>Arsenites--toxicity<br/>Cell Line<br/>Cytoprotection<br/>Dose-Response Relationship, Drug<br/>Down-Regulation<br/>Enzyme Inhibitors--pharmacology<br/>Heme Oxygenase-1--antagonists & inhibitors<br/>Humans<br/>Kidney Tubules, Proximal--drug effects<br/>Mitochondria--drug effects<br/>Mitogen-Activated Protein Kinases--metabolism<br/>NF-E2-Related Factor 2--metabolism<br/>NF-kappa B--metabolism<br/>Nuclear Proteins--metabolism<br/>Oxidative Stress--drug effects<br/>Pyrazines--pharmacology<br/>Reactive Oxygen Species--metabolism<br/>Signal Transduction--drug effects<br/>Sodium Compounds--toxicity<br/>Time Factors<br/>Transcription Factor AP-1--metabolism