Feng, Xuejiao

Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Dec 2015 - 368-79 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0929

10.1093/toxsci/kfv197 doi


Acetylation
Alkanesulfonic Acids--toxicity
Animals
Down-Regulation
Endocrine Disruptors--toxicity
Environmental Exposure--adverse effects
Estradiol--biosynthesis
Estrous Cycle--drug effects
Female
Fluorocarbons--toxicity
Histones--metabolism
Hypothalamo-Hypophyseal System--drug effects
Mice, Inbred ICR
Neurons--drug effects
Neuropeptides--genetics
Ovarian Follicle--drug effects
Ovary--drug effects
Ovulation--drug effects
Phosphoproteins--genetics
Progesterone--blood
Promoter Regions, Genetic
RNA, Messenger--metabolism
Risk Assessment
Signal Transduction--drug effects
Time Factors
Toxicity Tests, Chronic
Steroidogenic Acute Regulatory Protein