Hosaka, Shinya

Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances. [electronic resource] - Biopharmaceutics & drug disposition Dec 2015 - 636-43 p. digital

Publication Type: Journal Article

1099-081X

10.1002/bdd.1991 doi


Animals
Biotransformation
Chromatography, High Pressure Liquid
Chromatography, Reverse-Phase
Cytochrome P-450 CYP2C19--genetics
Cytochrome P-450 CYP2C9--genetics
Histamine H1 Antagonists, Non-Sedating--chemistry
Humans
Isoenzymes--genetics
Loratadine--analogs & derivatives
Macaca fascicularis--metabolism
Molecular Structure
Oxidation-Reduction
Recombinant Proteins--metabolism
Spectrometry, Mass, Electrospray Ionization
Substrate Specificity
Tandem Mass Spectrometry
Xenobiotics--chemistry