TY - GEN AU - Llovet,Patricia AU - Sastre,Javier AU - Ortega,Julián Sanz AU - Bando,Inmaculada AU - Ferrer,Milagros AU - García-Alfonso,Pilar AU - Donnay,Olga AU - Carrato,Alfredo AU - Jiménez,Ana AU - Aranda,Enrique AU - León,Ana AU - Grávalos,Cristina AU - Cámara,Juan Carlos AU - Feliú,Jaime AU - Sanchíz,Bárbara AU - Caldés,Trinidad AU - Díaz-Rubio,Eduardo TI - Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy SN - 1179-2000 PY - 2016///0905 KW - Adult KW - Aged KW - Aged, 80 and over KW - Amphiregulin KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Class I Phosphatidylinositol 3-Kinases KW - Codon KW - Colorectal Neoplasms KW - drug therapy KW - DNA Copy Number Variations KW - DNA Mutational Analysis KW - Disease-Free Survival KW - EGF Family of Proteins KW - genetics KW - Epiregulin KW - ErbB Receptors KW - antagonists & inhibitors KW - Female KW - Gene Dosage KW - Gene Expression KW - Humans KW - Kaplan-Meier Estimate KW - Male KW - Middle Aged KW - Multivariate Analysis KW - Mutation, Missense KW - Neoplasm Metastasis KW - PTEN Phosphohydrolase KW - Phosphatidylinositol 3-Kinases KW - Prognosis KW - Proportional Hazards Models KW - Proto-Oncogene Proteins B-raf KW - Proto-Oncogene Proteins p21(ras) KW - ROC Curve KW - Retrospective Studies KW - Treatment Outcome N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1007/s40291-015-0165-0 ER -