TY - GEN AU - van der Hoeven,Sophia M AU - Binnekade,Jan M AU - de Borgie,Corianne A J M AU - Bosch,Frank H AU - Endeman,Henrik AU - Horn,Janneke AU - Juffermans,Nicole P AU - van der Meer,Nardo J M AU - Merkus,Maruschka P AU - Moeniralam,Hazra S AU - van Silfhout,Bart AU - Slabbekoorn,Mathilde AU - Stilma,Willemke AU - Wijnhoven,Jan Willem AU - Schultz,Marcus J AU - Paulus,Frederique TI - Preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE): study protocol for a randomized controlled trial SN - 1745-6215 PY - 2016///0610 KW - Acetylcysteine KW - administration & dosage KW - Administration, Inhalation KW - Albuterol KW - Bronchodilator Agents KW - Clinical Protocols KW - Cost-Benefit Analysis KW - Critical Illness KW - Drug Administration Schedule KW - Drug Costs KW - Drug Therapy, Combination KW - Expectorants KW - Hospital Mortality KW - Humans KW - Intensive Care Units KW - economics KW - Length of Stay KW - Nebulizers and Vaporizers KW - Netherlands KW - Pneumonia, Ventilator-Associated KW - etiology KW - Pulmonary Atelectasis KW - Research Design KW - Respiration, Artificial KW - adverse effects KW - Time Factors KW - Treatment Outcome N1 - Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/s13063-015-0865-0 ER -