TY - GEN AU - Hinson,John T AU - Chopra,Anant AU - Nafissi,Navid AU - Polacheck,William J AU - Benson,Craig C AU - Swist,Sandra AU - Gorham,Joshua AU - Yang,Luhan AU - Schafer,Sebastian AU - Sheng,Calvin C AU - Haghighi,Alireza AU - Homsy,Jason AU - Hubner,Norbert AU - Church,George AU - Cook,Stuart A AU - Linke,Wolfgang A AU - Chen,Christopher S AU - Seidman,J G AU - Seidman,Christine E TI - HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy SN - 1095-9203 PY - 2016///0219 KW - Adrenergic beta-Agonists KW - pharmacology KW - Cardiomyopathy, Dilated KW - genetics KW - Cells, Cultured KW - Connectin KW - chemistry KW - Heart Rate KW - Humans KW - Induced Pluripotent Stem Cells KW - physiology KW - Isoproterenol KW - Mutant Proteins KW - Mutation, Missense KW - Myocardial Contraction KW - Myocytes, Cardiac KW - RNA KW - Sarcomeres KW - Sequence Analysis, RNA KW - Signal Transduction KW - Stress, Physiological N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1126/science.aaa5458 ER -