20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway. [electronic resource]
- Drug design, development and therapy 2015
- 3969-87 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1177-8881
10.2147/DDDT.S84527 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Caspases--metabolism Cell Cycle Checkpoints--drug effects Cell Line, Tumor Cell Survival--drug effects Cellular Senescence--drug effects Cyclin-Dependent Kinase Inhibitor p21--metabolism Dose-Response Relationship, Drug Gallbladder Neoplasms--drug therapy Ginsenosides--pharmacology Humans Mice, Inbred BALB C Mice, Nude Mitochondria--drug effects Proto-Oncogene Proteins c-mdm2--metabolism Signal Transduction--drug effects Time Factors Tumor Burden--drug effects Tumor Suppressor Protein p53--metabolism Xenograft Model Antitumor Assays