Di Paolo, Daniela
New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK. [electronic resource]
- Oncotarget Oct 2015
- 28774-89 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
ISSN: 1949-2553
Standard No.: 10.18632/oncotarget.4342 doi
Subjects--Topical Terms: Anaplastic Lymphoma Kinase Animals Antineoplastic Agents--pharmacokinetics Biological Availability Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Combined Modality Therapy Dose-Response Relationship, Drug Female Gene Expression Regulation, Enzymologic--drug effects Gene Expression Regulation, Neoplastic--drug effects Half-Life Humans Liposomes Male Mice, Inbred BALB C Mice, Nude Molecular Targeted Therapy Mutation Nanoparticles Neuroblastoma--enzymology Protein Kinase Inhibitors--pharmacokinetics RNA Interference RNA, Small Interfering--genetics RNAi Therapeutics Receptor Protein-Tyrosine Kinases--antagonists & inhibitors Signal Transduction--drug effects Transfection Tumor Burden--drug effects Xenograft Model Antitumor Assays