TY  - GEN
AU  - Alqahtani,Saeed
AU  - Kaddoumi,Amal
TI  - Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability
SN  - 1099-081X
PY  - 2016///1014
KW  - Adult
KW  - Animals
KW  - Antiparkinson Agents
KW  - blood
KW  - Biological Availability
KW  - Biotransformation
KW  - Caco-2 Cells
KW  - Catechol O-Methyltransferase Inhibitors
KW  - Catechols
KW  - Computational Biology
KW  - Enterocytes
KW  - metabolism
KW  - Expert Systems
KW  - Humans
KW  - Intestinal Absorption
KW  - Liver
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Models, Biological
KW  - Nitriles
KW  - Phosphorylation
KW  - Prodrugs
KW  - analysis
KW  - Rats
KW  - Solubility
KW  - Tissue Distribution
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1002/bdd.1986
ER  -