Alqahtani, Saeed <br/><br/>
Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability.  [electronic resource] 

 -  Biopharmaceutics & drug disposition  Dec 2015 
 - 587-602 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1099-081X 
<br/><br/><label>Standard No.: </label>10.1002/bdd.1986  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Animals<br/>Antiparkinson Agents--blood<br/>Biological Availability<br/>Biotransformation<br/>Caco-2 Cells<br/>Catechol O-Methyltransferase Inhibitors--blood<br/>Catechols--blood<br/>Computational Biology<br/>Enterocytes--metabolism<br/>Expert Systems<br/>Humans<br/>Intestinal Absorption<br/>Liver--metabolism<br/>Male<br/>Metabolic Clearance Rate<br/>Models, Biological<br/>Nitriles--blood<br/>Phosphorylation<br/>Prodrugs--analysis<br/>Rats<br/>Solubility<br/>Tissue Distribution