TY - GEN AU - de Groof,E Joline AU - Buskens,Christianne J AU - Ponsioen,Cyriel Y AU - Dijkgraaf,Marcel G W AU - D'Haens,Geert R A M AU - Srivastava,Nidhi AU - van Acker,Gijs J D AU - Jansen,Jeroen M AU - Gerhards,Michael F AU - Dijkstra,Gerard AU - Lange,Johan F M AU - Witteman,Ben J M AU - Kruyt,Philip M AU - Pronk,Apollo AU - van Tuyl,Sebastiaan A C AU - Bodelier,Alexander AU - Crolla,Rogier M P H AU - West,Rachel L AU - Vrijland,Wietske W AU - Consten,Esther C J AU - Brink,Menno A AU - Tuynman,Jurriaan B AU - de Boer,Nanne K H AU - Breukink,Stephanie O AU - Pierik,Marieke J AU - Oldenburg,Bas AU - van der Meulen,Andrea E AU - Bonsing,Bert A AU - Spinelli,Antonino AU - Danese,Silvio AU - Sacchi,Matteo AU - Warusavitarne,Janindra AU - Hart,Ailsa AU - Yassin,Nuha A AU - Kennelly,Rory P AU - Cullen,Garret J AU - Winter,Desmond C AU - Hawthorne,A Barney AU - Torkington,Jared AU - Bemelman,Willem A TI - Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial SN - 1745-6215 PY - 2016///0502 KW - Anti-Inflammatory Agents KW - adverse effects KW - Combined Modality Therapy KW - Cost-Benefit Analysis KW - Crohn Disease KW - diagnosis KW - Digestive System Surgical Procedures KW - Drainage KW - Drug Therapy, Combination KW - Europe KW - Gastrointestinal Agents KW - Health Care Costs KW - Humans KW - Magnetic Resonance Imaging KW - Mercaptopurine KW - therapeutic use KW - Quality of Life KW - Rectal Fistula KW - Surveys and Questionnaires KW - Time Factors KW - Treatment Outcome KW - Tumor Necrosis Factor-alpha KW - antagonists & inhibitors N1 - Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/s13063-015-0831-x ER -