Uckun, Fatih M <br/><br/>
Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice.  [electronic resource] 

 -  EBioMedicine  Jun 2015 
 - 554-62 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>2352-3964 
<br/><br/><label>Standard No.: </label>10.1016/j.ebiom.2015.04.005  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Bone Marrow Transplantation<br/>Cell Line, Tumor<br/>Combined Modality Therapy--methods<br/>Disease-Free Survival<br/>Fusion Proteins, bcr-abl--genetics<br/>Gene Expression--drug effects<br/>Humans<br/>Intracellular Signaling Peptides and Proteins--antagonists & inhibitors<br/>Liposomes--therapeutic use<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Inbred NOD<br/>Mice, SCID<br/>Mice, Transgenic<br/>Nanoparticles<br/>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma--mortality<br/>Protein Kinase Inhibitors--therapeutic use<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Radiation Tolerance--drug effects<br/>Radiation-Sensitizing Agents--therapeutic use<br/>Syk Kinase<br/>Treatment Outcome<br/>Whole-Body Irradiation<br/>Xenograft Model Antitumor Assays