Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Jan 2016
- 107-21 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1557-3265
10.1158/1078-0432.CCR-15-0235 doi
Anilides--pharmacology Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Bone Neoplasms--diagnosis Cell Line, Tumor Clinical Trials, Phase II as Topic Disease Models, Animal Drug Resistance, Neoplasm Gene Knockdown Techniques Humans Male Mice Multicenter Studies as Topic Neoplasm Staging Phosphorylation Positron-Emission Tomography Prostatic Neoplasms--drug therapy Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins c-met--antagonists & inhibitors Pyridines--pharmacology Receptor, Fibroblast Growth Factor, Type 1--metabolism Signal Transduction--drug effects Treatment Outcome Tumor Burden--drug effects Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors Xenograft Model Antitumor Assays