TY  - GEN
AU  - Hammitzsch,Ariane
AU  - Tallant,Cynthia
AU  - Fedorov,Oleg
AU  - O'Mahony,Alison
AU  - Brennan,Paul E
AU  - Hay,Duncan A
AU  - Martinez,Fernando O
AU  - Al-Mossawi,M Hussein
AU  - de Wit,Jelle
AU  - Vecellio,Matteo
AU  - Wells,Christopher
AU  - Wordsworth,Paul
AU  - Müller,Susanne
AU  - Knapp,Stefan
AU  - Bowness,Paul
TI  - CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
SN  - 1091-6490
PY  - 2015///1230
KW  - Adult
KW  - Aged
KW  - Arthritis, Psoriatic
KW  - metabolism
KW  - Azepines
KW  - pharmacology
KW  - Benzimidazoles
KW  - chemistry
KW  - CD4-Positive T-Lymphocytes
KW  - drug effects
KW  - Calorimetry
KW  - Cells, Cultured
KW  - Crystallography, X-Ray
KW  - Drug Evaluation, Preclinical
KW  - Female
KW  - Gene Expression Regulation
KW  - Humans
KW  - Immunosuppressive Agents
KW  - Interleukin-17
KW  - biosynthesis
KW  - Isoxazoles
KW  - Kinetics
KW  - Male
KW  - Middle Aged
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Protein Conformation
KW  - Protein Structure, Tertiary
KW  - Recombinant Proteins
KW  - Spondylitis, Ankylosing
KW  - Structure-Activity Relationship
KW  - Th17 Cells
KW  - Triazoles
KW  - p300-CBP Transcription Factors
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1073/pnas.1501956112
ER  -