A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. [electronic resource]
- Molecular therapy : the journal of the American Society of Gene Therapy Nov 2015
- 1722-1733 p. digital
Publication Type: Journal Article
1525-0024
10.1038/mt.2015.127 doi
Animals Antibodies, Monoclonal--therapeutic use Antibodies, Monoclonal, Humanized--pharmacology Antineoplastic Agents--pharmacology Antineoplastic Combined Chemotherapy Protocols--pharmacology Apoptosis--drug effects Cell Proliferation Humans Immunoglobulin Fc Fragments--pharmacology MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Neoplasms--drug therapy Receptor, ErbB-2--antagonists & inhibitors Signal Transduction Trastuzumab--pharmacology Xenograft Model Antitumor Assays