Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation. [electronic resource]
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov 2015
- 4641-53 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1530-6860
10.1096/fj.15-272732 doi
Animals Autophagy--drug effects Coenzyme A Ligases--deficiency Mechanistic Target of Rapamycin Complex 1 Mice Mice, Knockout Mitochondria, Heart--genetics Multiprotein Complexes--genetics Myocardium--metabolism Oxygen Consumption--drug effects Proton-Translocating ATPases--metabolism Sirolimus--pharmacology TOR Serine-Threonine Kinases--genetics