Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation. [electronic resource]
- Oncotarget Sep 2015
- 25646-59 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.4662 doi
Antineoplastic Agents--metabolism Apoptosis--drug effects Arsenic Trioxide Arsenicals--metabolism Biotransformation Cacodylic Acid--analogs & derivatives Cell Differentiation--drug effects Cell Proliferation--drug effects Dose-Response Relationship, Drug HEK293 Cells HeLa Cells Humans Leukemia, Promyelocytic, Acute--drug therapy Methylation Nuclear Proteins--metabolism Oncogene Proteins, Fusion--metabolism Organometallic Compounds--metabolism Oxides--metabolism Promyelocytic Leukemia Protein Proteasome Endopeptidase Complex--metabolism Protein Binding Protein Interaction Domains and Motifs Proteolysis Sumoylation Time Factors Transcription Factors--metabolism Tumor Suppressor Proteins--metabolism