Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. [electronic resource]
- The international journal of biochemistry & cell biology Sep 2015
- 75-84 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1878-5875
10.1016/j.biocel.2015.07.009 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Breast Neoplasms--drug therapy Cell Line Cell Transformation, Neoplastic--drug effects Curcumin--pharmacology Cyclin-Dependent Kinase Inhibitor p21--genetics Drug Synergism Epithelial Cells--drug effects Female Hedgehog Proteins--metabolism Humans Immunoblotting Mice, Inbred BALB C Microscopy, Fluorescence RNA Interference Resveratrol Signal Transduction--drug effects Smoke Stilbenes--pharmacology Nicotiana--chemistry Transcription Factors--genetics Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 bcl-2-Associated X Protein--metabolism bcl-X Protein--metabolism