TY  - GEN
AU  - Holzer,Philipp
AU  - Masuya,Keiichi
AU  - Furet,Pascal
AU  - Kallen,Joerg
AU  - Valat-Stachyra,Therese
AU  - Ferretti,Stéphane
AU  - Berghausen,Joerg
AU  - Bouisset-Leonard,Michèle
AU  - Buschmann,Nicole
AU  - Pissot-Soldermann,Carole
AU  - Rynn,Caroline
AU  - Ruetz,Stephan
AU  - Stutz,Stefan
AU  - Chène,Patrick
AU  - Jeay,Sébastien
AU  - Gessier,Francois
TI  - Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors
SN  - 1520-4804
PY  - 2015///1116
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Line, Tumor
KW  - Clinical Trials, Phase I as Topic
KW  - Drug Discovery
KW  - Humans
KW  - Isoquinolines
KW  - Piperazines
KW  - Proto-Oncogene Proteins c-mdm2
KW  - antagonists & inhibitors
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Tumor Suppressor Protein p53
KW  - genetics
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.5b00810
ER  -