Holzer, Philipp <br/><br/>
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2015 
 - 6348-58 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b00810  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Cell Line, Tumor<br/>Clinical Trials, Phase I as Topic<br/>Drug Discovery<br/>Humans<br/>Isoquinolines--chemical synthesis<br/>Piperazines--chemical synthesis<br/>Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors<br/>Rats<br/>Structure-Activity Relationship<br/>Tumor Suppressor Protein p53--genetics<br/>Xenograft Model Antitumor Assays