TY  - GEN
AU  - Bonaventure,Pascal
AU  - Shelton,Jonathan
AU  - Yun,Sujin
AU  - Nepomuceno,Diane
AU  - Sutton,Steven
AU  - Aluisio,Leah
AU  - Fraser,Ian
AU  - Lord,Brian
AU  - Shoblock,James
AU  - Welty,Natalie
AU  - Chaplan,Sandra R
AU  - Aguilar,Zuleima
AU  - Halter,Robin
AU  - Ndifor,Anthony
AU  - Koudriakova,Tatiana
AU  - Rizzolio,Michele
AU  - Letavic,Michael
AU  - Carruthers,Nicholas I
AU  - Lovenberg,Timothy
AU  - Dugovic,Christine
TI  - Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
SN  - 1521-0103
PY  - 2015///1006
KW  - Animals
KW  - Binding Sites
KW  - drug effects
KW  - Brain
KW  - CHO Cells
KW  - Cell Line
KW  - Cricetulus
KW  - Dopamine
KW  - metabolism
KW  - HEK293 Cells
KW  - Humans
KW  - Hypnotics and Sedatives
KW  - pharmacology
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Orexin Receptor Antagonists
KW  - Pyridines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Sleep
KW  - Sleep Initiation and Maintenance Disorders
KW  - drug therapy
KW  - Sleep Stages
KW  - Sleep, REM
KW  - Zolpidem
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/jpet.115.225466
ER  -