Bonaventure, Pascal <br/><br/>
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  Sep 2015 
 - 471-82 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-0103 
<br/><br/><label>Standard No.: </label>10.1124/jpet.115.225466  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Binding Sites--drug effects<br/>Brain--drug effects<br/>CHO Cells<br/>Cell Line<br/>Cricetulus<br/>Dopamine--metabolism<br/>HEK293 Cells<br/>Humans<br/>Hypnotics and Sedatives--pharmacology<br/>Male<br/>Mice<br/>Mice, Knockout<br/>Orexin Receptor Antagonists<br/>Pyridines--pharmacology<br/>Rats<br/>Rats, Sprague-Dawley<br/>Sleep--drug effects<br/>Sleep Initiation and Maintenance Disorders--drug therapy<br/>Sleep Stages--drug effects<br/>Sleep, REM--drug effects<br/>Zolpidem