Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways. [electronic resource]
- Molecular medicine reports Oct 2015
- 5573-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1791-3004
10.3892/mmr.2015.4068 doi
Aggrecans--agonists Animals Cartilage, Articular--cytology Chondrocytes--cytology Collagen Type II--agonists Enzyme Activation Female Flavonoids--pharmacology Gene Expression Regulation Humans Imidazoles--pharmacology Isoquinolines--pharmacology Mitogen-Activated Protein Kinase 1--genetics Mitogen-Activated Protein Kinase 3--genetics Phosphorylation--drug effects Primary Cell Culture Protein Serine-Threonine Kinases--antagonists & inhibitors Pyridines--pharmacology Pyrroles--pharmacology Quinoxalines--pharmacology Rats Rats, Sprague-Dawley Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta--antagonists & inhibitors Recombinant Proteins--metabolism Signal Transduction Smad2 Protein--agonists Smad3 Protein--agonists Transforming Growth Factor beta1--metabolism