Zhu, Yanhui

Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways. [electronic resource] - Molecular medicine reports Oct 2015 - 5573-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1791-3004

10.3892/mmr.2015.4068 doi


Aggrecans--agonists
Animals
Cartilage, Articular--cytology
Chondrocytes--cytology
Collagen Type II--agonists
Enzyme Activation
Female
Flavonoids--pharmacology
Gene Expression Regulation
Humans
Imidazoles--pharmacology
Isoquinolines--pharmacology
Mitogen-Activated Protein Kinase 1--genetics
Mitogen-Activated Protein Kinase 3--genetics
Phosphorylation--drug effects
Primary Cell Culture
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyridines--pharmacology
Pyrroles--pharmacology
Quinoxalines--pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta--antagonists & inhibitors
Recombinant Proteins--metabolism
Signal Transduction
Smad2 Protein--agonists
Smad3 Protein--agonists
Transforming Growth Factor beta1--metabolism