Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling. [electronic resource]
- Osteoarthritis and cartilage Dec 2015
- 2279-2287 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1522-9653
10.1016/j.joca.2015.06.020 doi
ADAM Proteins--genetics ADAMTS4 Protein ADAMTS5 Protein Adolescent Adult Apoptosis--drug effects Autophagy--drug effects Cartilage, Articular--cytology Case-Control Studies Chondrocytes--drug effects Collagen Type I--genetics Collagen Type II--genetics Dexamethasone--pharmacology Down-Regulation Female Femoracetabular Impingement--genetics Forkhead Box Protein O3 Forkhead Transcription Factors--drug effects Glucocorticoids--pharmacology Hip Joint Humans Matrix Metalloproteinase 1--genetics Matrix Metalloproteinase 13--genetics Procollagen N-Endopeptidase--genetics Proto-Oncogene Proteins c-akt--drug effects RNA, Messenger--metabolism Reactive Oxygen Species--metabolism Real-Time Polymerase Chain Reaction Signal Transduction--drug effects Up-Regulation Young Adult